Developed by the Ethier laboratory, the SLKBase provides researchers with comprehensive genomic, proteomic, and functional data derived from the SUM human breast cancer cell line panel.
Over decades of research, our laboratory established these cell lines, optimized their culture conditions, and mapped how their unique properties illuminate the biology of the original patient tumors. Today, the essentiality of every genomic feature within these lines is well-defined through genome-scale shRNA screens.
Explore the Data: Navigating massive datasets can be challenging. To make this wealth of information accessible, we developed a suite of straightforward data-mining apps designed to help you extract biologically meaningful insights quickly. I encourage you to give these tools a spin to see what you can uncover.
Beyond the SUM Panel The SLKBase has continuously evolved to meet the needs of the research community. Our resources now include:
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The SUM Panel: Complete genomic and proteomic profiling of the original Ethier laboratory cell lines.
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Expanded Breast Cancer Database: Detailed data for 50 additional, widely used human breast cancer cell lines.
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Pan-Cancer Web App: A recently launched tool providing access to functional genomic data for over 1,000 human cancer cell lines.
To make the SLKBase easier to use, I’ve created a series of YouTube videos that demonstrate our data mining tools. I recommend starting with the Introductory Navigation Video . These vidos are also available for direct download in the Data Download Center.
For a complete description of all that the SLKBase has to offer, check out the SLKBase page. Here you will find links to our protocols for the maintenance of each of the SUM lines.
Or, if you’re ready to dive in? Use the links below to access our data gateways:
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Explore the SUM breast cancer cell lines.
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View our expanded breast cancer panel.
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Access functional genomics for 900 human cancer cell lines.
If you encounter ANY problems with the website or if you encounter a broken link, please write to me at spethier@sumlineknowledgebase.com.
Thank you for being part of the SUM Cancer Cell Line Knowledge Base!
Steve Ethier
