We have now added what we refer to as the functional-druggable targets to the home pages for each cell line. To determine the signature of functional-druggable targets for each cell line, we used the list of targeted drugs linked to specific genes from the Genomics of Drug Sensitivity in Cancer data base, and cross-referenced that list with the list of genes that were hits in our functional screen for each cell line. The result is a list of functional (as defined by the screen) druggable targets for each cell line.
We also added the complete list of targeted drugs from the Genomics of Drug Sensitivity in Cancer data base to our own MySQL data base. As a result, when the KEGG Pathway Engine is used to view screen hits in specific pathways, the data table that comes with each pathway, lists the drugs associated with each hit in the functional screen.
Finally, each functional-druggable target is associated with a link to the KEGG web site that lists all of the pathways in which that particular target has been assigned. Thus, one way to mine the data for a particular functional-druggable target is to identify a pathway of interest that the target maps to, then go to the KEGG Pathway Engine and select the cell line and KEGG pathway from the drop down menus. This will allow you to visualize the position of the druggable target in each pathway, and you will also be able to see if there are multiple druggable targets in the pathway(s) .
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