SUM-52 Cells: Functional Druggable Signature

The functional-druggable signature for the SUM breast cancer cell lines represent the list of genes that were hits in our genome-scale shRNA screen for which targeted drugs exist.  Note that we have not tested the SUM lines for sensitivity to these targeted drugs, however, we hypothesize a link between gene essentiality and targeted drug sensitivity.
To view the pathways associated with each target, click on the Link to Pathways.  To view the druggable targets within individual pathways, use the KEGG Pathway Engine
Symbol EntrezId Existing Drugs Link to Pathways
KIF11 3832 S-Trityl-L-cysteine, Ispinesib Mesylate http://www.genome.jp/dbget-bin/www_bget?hsa:3832
BRD4 23476 JQ1, I-BET-762, PFI-1 http://www.genome.jp/dbget-bin/www_bget?hsa:23476
FLT4 2324 Cabozantinib, Linifanib, Tivozanib, XMD11-85h http://www.genome.jp/dbget-bin/www_bget?hsa:2324
CDK6 1021 AT-7519, Palbociclib http://www.genome.jp/dbget-bin/www_bget?hsa:1021
PTPN11 5781 NSC-87877 http://www.genome.jp/dbget-bin/www_bget?hsa:5781
MAP4K2 5871 NG-25 http://www.genome.jp/dbget-bin/www_bget?hsa:5871
FRAP1 2475 Rapamycin, JW-7-52-1, Omipalisib, OSI-027, Temsirolimus, Dactolisib, AZD8055, QL-VIII-58 http://www.genome.jp/dbget-bin/www_bget?hsa:2475
TOP1 7150 Camptothecin, SN-38 http://www.genome.jp/dbget-bin/www_bget?hsa:7150
PLK1 5347 BI-2536, GW843682X http://www.genome.jp/dbget-bin/www_bget?hsa:5347
CDK9 1025 CGP-60474, Seliciclib, AT-7519, TL-1-85, THZ-2-49, KIN001-270 http://www.genome.jp/dbget-bin/www_bget?hsa:1025
PRKCD 5580 Midostaurin, XMD11-85h http://www.genome.jp/dbget-bin/www_bget?hsa:5580
BCL2L1 598 Obatoclax Mesylate, Navitoclax, TW 37 http://www.genome.jp/dbget-bin/www_bget?hsa:598
ITK 3702 BMS-509744 http://www.genome.jp/dbget-bin/www_bget?hsa:3702
TBK1 29110 BX796 http://www.genome.jp/dbget-bin/www_bget?hsa:29110
DHX9 1660 YK-4-279 http://www.genome.jp/dbget-bin/www_bget?hsa:1660
PTK2B 2185 PF-562271 http://www.genome.jp/dbget-bin/www_bget?hsa:2185
IGF1R 3480 BMS-536924, BMS-754807, Linsitinib, GSK1904529A http://www.genome.jp/dbget-bin/www_bget?hsa:3480
XIAP 331 Embelin http://www.genome.jp/dbget-bin/www_bget?hsa:331
AKT1 207 A-443654, AKT inhibitor VIII, GSK690693, MK-2206 http://www.genome.jp/dbget-bin/www_bget?hsa:207
CSF1R 1436 Sunitinib, GW-2580, Pazopanib, Linifanib http://www.genome.jp/dbget-bin/www_bget?hsa:1436
RAF1 5894 Sorafenib http://www.genome.jp/dbget-bin/www_bget?hsa:5894

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