The Oncogene Signatures for the SUM-229 cell line

Candidate Oncogene Signature:  Genes that are genomically altered and OncoKB annotated
GeneSymbol DnaAmp LogFoldChange Mutation OccurencesInCOSMIC oncogene
RAD21 1.5757 0.608 NULL 0 0
RAD21 1.3294 0.6080 NULL 0 0
KRAS 1.1991 -0.218 KRASp.G12D 8837 1
GNAS 1.0307 -1.417 NULL 0 1
AURKA 1.0307 0.674 NULL 0 1
NCOA3 1.0307 1.655 NULL 0 0
TP53 NULL -0.845 TP53p.R273C 500 0

Functional Oncogene Signature: Genes that are genomically altered and were hits in our RNAi screen

GeneSymbol DnaAmp LogFoldChange Mutation OccurencesInCOSMIC ScreenHit
KRAS 1.1991 -0.2185 KRASp.G12D 8837 1
LRMP 1.1991 -0.25 NULL 0 1

Overall Oncogene Signature: Genes that are amplified and overexpressed or recurrently mutated regardless of OncoKB or RNAi status

GeneSymbol DnaAmp LogFoldChange Mutation ScreenHit OccurencesInCOSMIC ExistingDrugs
TRIB1 2.0429 3.257 NULL 0 0 NULL
MTSS1 2.0429 1.154 NULL 0 0 NULL
KRAS 1.1991 -0.218 KRASp.G12D 1 8837 NULL
TP53 NULL -0.847 TP53p.R273C 0 500 NULL

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