Gateway to 40 Breast Cancer Cell Lines

This gateway provides access to dedicated pages for 40 human breast cancer cell lines. To assist in identifying the most relevant models, each line is categorized by specific keywords. Individual cell line pages feature a concise summary, links to comprehensive genomic datasets, and a detailed Oncogene Signature accompanied by expert commentary.
Following the cell line summaries, three tables outline the drug sensitivities for each model, categorized into three tiers:
  • Tier 1: Includes drugs targeting bona fide oncogenes with structural alterations and high sensitivity (Z-score <-1.5).
  • Tier 2: Identifies drugs where sensitivity correlates with gene essentiality in CRISPR or RNAi screens, regardless of genomic status, indicating a likely on-target effect.
  • Tier 3: Features drugs with high sensitivity (Z-score < -1.5) despite the target not being a ‘hit’ in functional screens. These cases often involve multiple drugs hitting the same target or a single drug inhibiting redundant isoforms (e.g., AKT1/2/3), which explains the disconnect between screen results and drug response.

Click here to get to the data mining apps for the 40 additional breast cancer cell lines

  • AU565 (key words: HER2 amplified, ER-negative, HER2amp molecular subtype, pleural effusion)
  • BT549  (key words; triple negative, Claudin-low subtype, primary tumor derived, TP53 and PTEN mutant)
  • CAL51 (key words: Triple negative, Basal B, pleural effusion, PIK3CA mutant)
  • CAMA1  (key words: ER-positive, HER2negative, pleural effusion)
  • EFM19  (key words: ER-positive, HER2negative luminal cell line, PIK3CA mutant, TP53 mutant)
  • DU4475  (key words: ER-negative, HER2 negative, HER2amp molecular subtype.  metastatic skin nodule, BRAF mutant)
  • BT20  (key words: triple negative cell line, Basal A subtype, primary tumor derived, PIK3CA mutant)
  • CAL120  (key words: triple negative, pleural effusion, Basal B cell line)
  • HCC70  (key words; primary tumor derived, African American patient, triple negative, Basal A subtype)
  • HCC202  (key words: primary tumor derived, ER-negative, HER2 amplified)
  • HCC1143  (key words: primary tumor derived, ER-negative, HER2 negative, Basal A cell line)
  • HCC1187 (key words: primary tumor derived, ER-negative, HER2 negative, Basal A cell line)
  • HCC1395 (key words: primary tumor derived, ER-negative, HER2 negative, Basal A cell line)
  • HCC1419 (key words: primary tumor derived, Caucasian/Native American, ER-positive, HER2 amplified)
  • HCC1428 (key words: pleural effusion, ER-positive, HER2 negative)
  • HCC1500 (key words: primary tumor derived, ER-positive, HER2 negative)
  • HCC1569 (key words: primary tumor derived, African American patient, HER2 positive, ER-negative)
  • HCC1806 (key words: primary tumor derived-squamous breast ca, African American patient, ER-negative, HER2negative, Basal A)
  • HCC1937 (key words: primary tumor derived, ER-negative, HER2 negative, 24 year old patient, BRCA1 mutant, Basal A)
  • HCC1954 (key words: primary tumor derived, HER2 positive, ER-negative, South Asian ancestry)
  • HCC2218 (key words: primary tumor derived, HER2 positive, ER-negative, HER2 amp subtype)
  • HMC18 (key words: primary tumor derived, ER-negative, HER2 negative, Basal A cell line)
  • Hs578T (key words: pleural effusion, Asian ancestry, triple negative, Basal B, HRAS mutant)
  • JIMT1 (key words: pleural effusion, HER2 positive, ER-negative, PIK3CA mutant)
  • KPL1 (key words: Contaminated derivative of MCF-7)
  • MCF7 (key words: )pleural effusion, ER-positive, HER2 negative, PIK3CA mutant.  MCF=Michigan Cancer Foundation)
  • MDA-MB-231 (key words: pleural effusion, triple negative, KRAS mutant, Claudin low subtype)
  • MDA-MB-468 (key words: pleural effusion, African American patient, triple negative, EGFR amplified, RB1 mutant, PTEN mutant)
  • MDA-MB-134VI (key words: pleural effusion, ER-positive, HER2 negative, luminal subtype, 8p11 amplicon present)
  • MDA-MB-175VII (key words: pleural effusion, African American patient, ER-positive, HER2 negative, HER2 amp sub-type)
  • MDA-MB-157 (key words: pleural effusion, African American patient, Basal B subtype, CCNE1 amplified)
  • MDA-MB-361 (key words: brain metastasis derived, HER2 positive, ER-positive, PIK3CA mutant, HER2 amp subtype)
  • MDA-MB-415  (key words: ER-positive, HER2 negative, pleural effusion)
  • MDA-MB-436  (key words: triple negative, Basal B, BRCA1 mutant, pleural effusion)
  • MDA-MB-453  (key words:  ERBB2 amp/triple negative, cardiac effusion, hyper PI3’K-AKT signaling
  • SKBR3  (key words: ER-negative, HER2 positive, pleural effusion, POSSIBLY THE SAME CELL LINE AS AU565)
  • T47D  (key words; ER-positive, PR Positive, Her2 negative, pleural effusion)
  • UACC812  (key words: ER-positive, HER2 positive, primary tumor derived)
  • ZR7530 (ER-positive, HER2 positive)
  • ZR751  (key words: ER positive, malignant ascites, 8p11 amplicon, PTEN mutant)