SUM-149 Cells: Functional-druggable Signature - The SUM Cancer Cell Line Knowledge Base (SLKBase)

The functional-druggable signature for the SUM breast cancer cell lines represent the list of genes that were hits in our genome-scale shRNA screen for which targeted drugs exist. Note that we have not tested the SUM lines for sensitivity to these targeted drugs, however, we hypothesize a link between gene essentiality and targeted drug sensitivity.

To view the KEGG Pathways associated with each target, click on Link to Pathways. To view targets within specific pathways, use the KEGG Pathway Engine

Symbol	EntrezId	Existing Drugs	Link to Pathways
EGFR	1956	Erlotinib, Lapatinib, CUDC-101, Pelitinib, Gefitinib, Cetuximab, HG-5-88-01, Afatinib	http://www.genome.jp/dbget-bin/www_bget?hsa:1956
CHEK1	1111	AZD7762, 681640	http://www.genome.jp/dbget-bin/www_bget?hsa:1111
BIRC5	332	Sepantronium bromide	http://www.genome.jp/dbget-bin/www_bget?hsa:332
TOP1	7150	Camptothecin, SN-38	http://www.genome.jp/dbget-bin/www_bget?hsa:7150
PLK1	5347	BI-2536, GW843682X	http://www.genome.jp/dbget-bin/www_bget?hsa:5347
KIF11	3832	S-Trityl-L-cysteine, Ispinesib Mesylate	http://www.genome.jp/dbget-bin/www_bget?hsa:3832
PLK1	5347	BI-2536, GW843682X	http://www.genome.jp/dbget-bin/www_bget?hsa:5347
ITK	3702	BMS-509744	http://www.genome.jp/dbget-bin/www_bget?hsa:3702
PLK1	5347	BI-2536, GW843682X	http://www.genome.jp/dbget-bin/www_bget?hsa:5347
KIF11	3832	S-Trityl-L-cysteine, Ispinesib Mesylate	http://www.genome.jp/dbget-bin/www_bget?hsa:3832
PRKCD	5580	Midostaurin, XMD11-85h	http://www.genome.jp/dbget-bin/www_bget?hsa:5580
MAP3K7	6885	NG-25, (5Z)-7-Oxozeaenol	http://www.genome.jp/dbget-bin/www_bget?hsa:6885
BCL2L1	598	Obatoclax Mesylate, Navitoclax, TW 37	http://www.genome.jp/dbget-bin/www_bget?hsa:598
JAK2	3717	Ruxolitinib, Fedratinib, Lestauritinib	http://www.genome.jp/dbget-bin/www_bget?hsa:3717

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