SUM-185 cells: Functional-druggable signature

The functional-druggable signature for the SUM breast cancer cell lines represent the list of genes that were hits in our genome-scale shRNA screen for which targeted drugs exist.  Note that we have not tested the SUM lines for sensitivity to these targeted drugs, however, we hypothesize a link between gene essentiality and targeted drug sensitivity.
To view the pathways associated with each target, click on the Link to Pathways.  To view the druggable targets within individual pathways, use the KEGG Pathway Engine
Symbol EntrezId Existing Drugs Link to Pathways
BCL2L1 598 Obatoclax Mesylate, Navitoclax, TW 37 http://www.genome.jp/dbget-bin/www_bget?hsa:598
PIK3CD 5293 Idelalisib http://www.genome.jp/dbget-bin/www_bget?hsa:5293
FGFR3 2261 PD173074 http://www.genome.jp/dbget-bin/www_bget?hsa:2261
IKBKB 3551 BMS-345541, KIN001-260, TPCA-1 http://www.genome.jp/dbget-bin/www_bget?hsa:3551
DHFR 1719 Pyrimethamine http://www.genome.jp/dbget-bin/www_bget?hsa:1719
PRKCD 5580 Midostaurin, XMD11-85h http://www.genome.jp/dbget-bin/www_bget?hsa:5580
CDK9 1025 CGP-60474, Seliciclib, AT-7519, TL-1-85, THZ-2-49, KIN001-270 http://www.genome.jp/dbget-bin/www_bget?hsa:1025
RIPK1 8737 XMD13-2 http://www.genome.jp/dbget-bin/www_bget?hsa:8737
TEC 7006 Bosutinib http://www.genome.jp/dbget-bin/www_bget?hsa:7006
CDK6 1021 AT-7519, Palbociclib http://www.genome.jp/dbget-bin/www_bget?hsa:1021
HIPK2 28996 PI-103 http://www.genome.jp/dbget-bin/www_bget?hsa:28996
PRKCA 5578 Midostaurin http://www.genome.jp/dbget-bin/www_bget?hsa:5578
AKT1 207 A-443654, AKT inhibitor VIII, GSK690693, MK-2206 http://www.genome.jp/dbget-bin/www_bget?hsa:207
TBK1 29110 BX796 http://www.genome.jp/dbget-bin/www_bget?hsa:29110
NR1H2 7376 T0901317 http://www.genome.jp/dbget-bin/www_bget?hsa:7376
MAP4K2 5871 NG-25 http://www.genome.jp/dbget-bin/www_bget?hsa:5871
PTPN11 5781 NSC-87877 http://www.genome.jp/dbget-bin/www_bget?hsa:5781
FLT1 2321 Midostaurin, Cabozantinib, Linifanib, Tivozanib http://www.genome.jp/dbget-bin/www_bget?hsa:2321
CAPN1 823 MG-132 http://www.genome.jp/dbget-bin/www_bget?hsa:823
GSK3A 2931 CHIR-99021, SB216763 http://www.genome.jp/dbget-bin/www_bget?hsa:2931
MAPK7 5598 XMD8-85, BIX02189, XMD8-92 http://www.genome.jp/dbget-bin/www_bget?hsa:5598
LCK 3932 A-770041, WH-4-023, JW-7-24-1 http://www.genome.jp/dbget-bin/www_bget?hsa:3932
EGFR 1956 Erlotinib, Lapatinib, CUDC-101, Pelitinib, Gefitinib, Cetuximab, HG-5-88-01, Afatinib http://www.genome.jp/dbget-bin/www_bget?hsa:1956
PIK3CA 5290 A66, BKM120 http://www.genome.jp/dbget-bin/www_bget?hsa:5290

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