SUM-225 Cells: Functional-druggable Signature

The functional-druggable signature for the SUM breast cancer cell lines represent the list of genes that were hits in our genome-scale shRNA screen for which targeted drugs exist.  Note that we have not tested the SUM lines for sensitivity to these targeted drugs, however, we hypothesize a link between gene essentiality and targeted drug sensitivity.
To view the KEGG Pathways associated with each target, click on the Link to Pathways.  To view druggable targets within specific pathways, use the KEGG Pathway Engine
Symbol Entrez Id Existing Drugs Link to Pathways
TOP1 7150 Camptothecin, SN-38 http://www.genome.jp/dbget-bin/www_bget?hsa:7150
CHUK 1147 GSK319347A, BMS-345541 http://www.genome.jp/dbget-bin/www_bget?hsa:1147
FRAP1 2475 Rapamycin, JW-7-52-1, Omipalisib, OSI-027, Temsirolimus, Dactolisib, AZD8055, QL-VIII-58 http://www.genome.jp/dbget-bin/www_bget?hsa:2475
DHX9 1660 YK-4-279 http://www.genome.jp/dbget-bin/www_bget?hsa:1660
PRKCD 5580 Midostaurin, XMD11-85h http://www.genome.jp/dbget-bin/www_bget?hsa:5580
KIF11 3832 S-Trityl-L-cysteine, Ispinesib Mesylate http://www.genome.jp/dbget-bin/www_bget?hsa:3832
NR1H2 7376 T0901317 http://www.genome.jp/dbget-bin/www_bget?hsa:7376
HDAC3 8841 Entinostat http://www.genome.jp/dbget-bin/www_bget?hsa:8841
EDNRA 1909 Zibotentan http://www.genome.jp/dbget-bin/www_bget?hsa:1909
RAC1 5879 EHT-1864 http://www.genome.jp/dbget-bin/www_bget?hsa:5879
PLK1 5347 BI-2536, GW843682X http://www.genome.jp/dbget-bin/www_bget?hsa:5347
BRD4 23476 JQ1, I-BET-762, PFI-1 http://www.genome.jp/dbget-bin/www_bget?hsa:23476
ERBB2 2064 Lapatinib, CP724714, CUDC-101, Afatinib http://www.genome.jp/dbget-bin/www_bget?hsa:2064
PIK3CA 5290 A66, BKM120 http://www.genome.jp/dbget-bin/www_bget?hsa:5290

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