SUM-52 genes that are amplified, overexpressed and were hits in the RNAi screen (functional oncogenes)

The Candidate Oncogene Signature for the SUM-52 cell line can be downloaded below.  This list represents all of the genes that are considered to be oncogenes and that were genomically altered in this cell  line.  The table shows the genomic status as well as the essentiality of each candidate oncogene in this cell line.  The Functional Oncogenes for this cell line are shown in red.  For a complete description of all three oncogene signatures for this cell line, please use the Oncogene Signatures Tool here.

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GeneSymbolQuantLogRankScreenHitLogFoldChangeDnaAmpMutationOccurencesInCosmicExistingDrugs
FGFR27213.6812.569NA0PD173074
CDK612611.0464858381.581NA0AT-7519, Palbociclib
CDKN2A5421-0.043545459NACDKN2Ap.A68V3NA
GNAS67810.1954963690.9925NA0NA
CD79B8521NA1.182NA0NA
PRSS115910-1.68277301NAPRSS1p.K170E1NA
ERCC221460NA1.6458NA0NA
BRIP1225300.199013611.182NA0NA
HGF29300-0.6077314231.2541NA0NA
WHSC1L1500001.5332649512.1959NA0NA
PAK1552501.1307290412.1705NA0IPA-3
MDM2560400.0234250110.8609NA0Nutlin-3a (-), Serdemetan
DNAJB1648300.7327957341.4894NA0NA
NCOA365010-0.6568395870.9171NA0NA
CIC75150-0.357895991.6458NA0NA
FGFR188080-0.4999658852.1959NA0Midostaurin, Ponatinib, PD173074
BBC310986.500.3928992841.6458NA0NA