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April 29, 2026

The SUM Cancer Cell Line Knowledge Base (SLKBase)

Using functional genomics to navigate critical pathways for growth and survival of breast cancer cells

  • Welcome Cancer Researchers!
    • Contact Us
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  • SLKBase!
    • Key features of this cell line panel
    • Why is it important to have a breast cancer cell line knowledge base?
    • The Omic data sets that were used to develop the SLKBase
    • SLKBase Functional Cancer Cell Line Genomics by Sextant Oncology LLC
    • Functional Druggable Signatures for the SUM cell lines
    • See what we’re working on to make the Knowledge Base better
    • SUM Cell Lines Gateway Page
    • About Steve Ethier
    • Blog posts on the SUM breast cancer cell lines
    • YouTube Video and Data Download Center
    • SUM line media and protocols
      • SUM Cell lines culture media
      • Media components
      • How to prepare materials for growth media
    • Please join the SLKBase email list on MailChimp
  • Gateway to the SUM Breast Cancer Cell Lines
    • SUM-44 Home
      • The Story of the SUM-44PE cell line
      • Bibliography of published papers in which SUM-44 cells were used
      • Narrative summary of molecular and cellular characteristics of the SUM-44PE cells
      • Oncogene Signatures for SUM-44PE cells
      • The KEGG canonical pathways enriched with data from our genome-scale shRNA screen in SUM-44 cells
        • Cell Cycle Pathway
        • PI3’K/AKT pathway
        • WNT Pathway
        • Hippo Pathway
        • MAPK Signaling
        • Apoptosis
        • Cytokine-Cytokine Receptor Interaction
        • ECM Receptor interaction
      • SUM-44 cells: Functional-druggable signature
      • Drug Sensitivity Data for functional-druggable targets of SUM-44 cells
        • SUM-44: Sensitivity to Navitoclax
        • SUM-44: Sensitivity to Palbociclib
        • SUM-44: Sensitivity to the PIK3CD inhibitor, Idelalisib
      • STR Profile for SUM-44 cells
    • SUM-52 Home
      • Derivation of the SUM-52PE breast cancer cell line
      • Bibliography of published papers in which SUM-52 cells were used
      • Narrative Summary of the SUM-52PE cell line
      • The Oncogenes of the SUM-52PE breast cancer cell line
        • SUM-52 genes that are amplified, overexpressed and were hits in the RNAi screen (functional oncogenes)
        • SUM-52 functional oncogene signature
      • The KEGG canonical pathways enriched with data from our genome-scale shRNA screen with SUM-52 cells
        • SUM-52 Cell Cycle pathway
        • SUM-52 PI3’K/AKT pathway
        • SUM-52 WNT pathway
        • SUM-52 Hippo Pathway
        • SUM-52 Apoptosis
        • SUM-52 MAPK signaling
        • SUM-52 ECM-Receptor Interaction
        • SUM-52 Cytokine-Cytokine Receptor Interaction
        • SUM-52 mTOR Pathway
        • SUM-52 Breast Cancer Pathway
        • SUM-52 Signaling Pathways Regulating Pluripotency of Stem Cells
      • SUM-52 Cells: Functional Druggable Signature
        • Drug sensitivities for SUM-52’s functional-druggable oncogenes
      • SUM-52 Differential drug sensitivity data
    • SUM-102 Home
      • Characteristics of the patient specimen from which SUM-102 was derived
      • SUM-102 Bibliography
      • The KEGG canonical pathways enriched with data from our genome-scale shRNA screen
        • SUM-102 Cell Cycle Pathway
        • SUM-102 ERBB Signaling
        • SUM-102 Apoptosis signalig
        • SUM-102 Jak-STAT pathway
        • SUM-102 MAPK signaling
        • SUM-102 mTOR signaling
        • SUM-102 PI3’K/AKT signaling
        • SUM-102 Focal Adhesion Signaling
        • SUM-102 ECM-Receptor Interaction
      • Narrative Summary of the SUM-102 Cell Line
      • The Candidate Oncogene Signature for SUM-159 cells.
      • SUM-102 cells: Functional-druggable Signature
      • STR Profile for SUM-102 cells
    • SUM-149 Home
      • Characteristics of the patient from which SUM-149PT was derived
      • SUM-149 Bibliography
      • Narrative Summary of the SUM-149 Cell Line
      • Functional amplified oncogenes in SUM-149PT cells
      • Mutational Oncogene Signature of SUM-149PT cells
      • KEGG canonical pathways enriched with data from the genome scale shRNA screen
        • SUM-149 PT Cell Cycle
        • SUM-149PT PI3’K/AKT Signaling
        • SUM-149PT mTOR signaling
        • SUM-149 PT ERBB Signaling Pathway
        • SUM-149PT MAPK Signaling
        • SUM-149PT WNT Signaling
        • SUM-149PT Apoptosis signaling
      • SUM-149 Cells: Functional-druggable Signature
      • SUM-149 Differential Drug Sensitivity Data
    • SUM-159 Home
      • Characteristics of the patient from which SUM-159 was derived
      • SUM-159 Bibliography
      • The oncogenes of the SUM-159 cell line
      • The KEGG canonical pathways enriched with data from our genome-scale shRNA screen
        • Signaling pathways regulating pluripotency in cancer
        • SUM-159 WNT signaling
        • SUM-159 PI3’K/AKT signaling
        • SUM-159 MAPK signaling
        • SUM-159 Hippo Signaling
        • SUM-159 Cell Cycle
      • SUM-159 cells: Functional-druggable Signature
      • SUM-159 Differential Drug Sensitivity Data
    • SUM-185PE Home
      • Derivation of the SUM-185PE cell line
      • SUM-185PE Bibliograpy
      • Narrative Summary of the SUM-185PE cell line
      • SUM-185 Oncogene Signatures
      • KEGG pathways enriched with screen hit data for SUM-185
        • SUM-185 Cell Cycle Pathway
        • SUM-185PE PI3’kinase/AKT pathway
        • SUM-185 Hippo Signaling
        • SUM-185 MAPK pathway: Genes that were hits in the screen
        • SUM-185 TGF-Beta signaling
        • SUM-185 WNT signaling
        • SUM-185PE Apoptosis
        • SUM-185 FoxO signaling
        • SUM-185PE Focal Adhesion Signaling
      • SUM-185 cells: Functional-druggable signature
      • SUM-185 Differential Drug Sensitivity (uM)
    • SUM-190 Home
      • Characteristics of the patient from which SUM-190 was derived and derivation of the cell line
      • SUM-190 Bibliography
      • The SUM-190 Oncogene Signatures
      • The point mutational oncogene signature of SUM-190
      • Narrative Summary of the SUM-190 Cell Line
      • The KEGG canonical pathways enriched with data from our genome-scale shRNA screen
        • SUM-190 Cell Cycle Pathway
        • SUM-190 PI3’K/AKT Pathway
        • SUM-190 Phosphatidylinositol Signaling System
        • SUM-190 mTOR Signaling
        • SUM-190 ERBB Signaling Pathway
        • SUM-190 MAPK Signaling Pathway
        • SUM-190 WNT Signaling
        • SUM-190 Apoptosis Signaling Pathway
        • SUM-190 ECM Receptor Interaction
        • SUM-190 Hippo Signaling
      • SUM-190 Cells: Functional-druggable Signature
    • SUM-225 Home
      • SUM-225 Characteristics of the patient from which SUM-225 was derived
      • SUM-225 Bibliograpy
      • SUM-225 Oncogene Signatures
      • SUM-225 point mutational oncogene signature
      • SUM-225 KEGG pathways enriched with data from the genome-scale shRNA screen
        • SUM-225 Cell cycle
        • SUM-225 ERBB signaling
        • SUM-225 PI3’K/AKT signaling
        • SUM-225 MAPK signaling
        • SUM-225 Apoptosis signaling
        • SUM-225 FOXO signaling
        • SUM-225 Hedgehog Signaling
        • SUM-225 HIF-1 Signaling
        • SUM-225 TGF-beta signaling
        • SUM-225 RAS signaling
        • SUM-225 mTOR signaling
        • SUM-225 WNT signaling
        • SUM-225 Hippo Signaling
        • SUM-225 Signaling pathways regulating pluripotency in stem cells
      • SUM-225 Cells: Functional-druggable Signature
      • STR Profile for SUM-225 cells
      • SUM225 differential drug sensitivity data
    • SUM-229 Home
      • Derivation of the SUM-229 cell line
      • SUM-229 Bibliography
      • The Oncogene Signatures for the SUM-229 cell line
      • Narrative Summary of the SUM-229 cell line
      • The KEGG canonical pathways enriched with data from our genome-scale shRNA screen of SUM-229
        • SUM-229 Cell Cycle
        • SUM-229 PI3’K/AKT signaling
        • SUM-229 MAPK Signaling
        • SUM-229 Apoptosis Signaling
        • SUM-229 TGF-beta signaling
        • SUM-229 WNT Signaling
        • SUM-229 Phosphatidylinositol signaling system
        • SUM-229 Hippo Signaling
        • SUM-229 RAS Signaling
      • SUM-229 Cells: Functional-druggable Signature
    • SUM-1315 Home
      • Derivation of the SUM-1315 breast cancer cell line
      • SUM-1315 Bibliograpy
      • The Oncogene Signatures of the SUM-1315 cell line
      • The KEGG canonical pathways enriched with data from our genome-scale shRNA screen
        • SUM-1315 Cell Cycle
        • SUM-1315 Cell Adhesion Molecules
        • SUM-1315 FOXO Signaling
        • SUM-1315 Hippo Signaling
        • SUM-1315 WNT Signaling
        • SUM-1315 Signaling pathways regulating pluripotency in stem cells
        • SUM-1315 PI3’K/AKT Signaling
        • SUM-1315 TGF-beta Signaling
      • SUM1315 cells: Functional-druggable signature
      • SUM-1315 Differential Drug Sensitivity Data (uM)
    • Data mining tools for the SUM breast cancer cell lines
      • Oncogene Signature Tool
      • SUM-line KEGG pathway engine
        • KEGG Pathway Engine tutorial
      • KEGG Pathway Analysis tool:
      • KEGG Pathway Druggable Functional Pathway Analysis:
      • Sum Line Gene Query
      • Proteomics and Phophoproteomic data for the SUM breast cancer cell line
      • Proteomic analysis of the SUM cell lines. Graphs of key proteins
        • Unsupervised cluster analysis of the RPPA results derived from the SUM cell lines
        • ER, AR, and GATA 3 expression in the SUM lines
        • AKT-pS308, AKT-pT473, PTEN, RPS6, RPS6-pS235, RPS6-pS240
        • Annexin1, Notch1, Taz, Mct4, Sox2, Vhl-Eppk1
        • Bcl2, Bcl-xL, MCL1, Bid, Bim
        • beta-catenin, p53, c-Myc, Brd4, Prex1
        • Caveolin1, connexin43, E-cadherin, EMA, FN1
        • CyclinD1, CyclinD3, GAB2
        • Dusp4, p16ink4, Pai-1, p21, Rad51, Fasn
        • Her2, HER2 (minus amplified cell lines), Her3, Egfr
        • PKCa, Syk, Axl
        • Src, Src-pY416, Src-pY527, p38Mapk, Shc-pY317, Shp2 pY542
        • Vegfr2, Igfbp2, Ndrg1, Met-pY1234
    • HOW TO ACQUIRE THE SUM BREAST CANCER CELL LINES
      • Why it is important for investigators to obtain cancer cell lines from a reputable source
  • Gateway to 40 Breast Cancer Cell Lines
    • Data Mining Tools for the Additional Breast Cancer Cell Lines
      • Oncogene Signatures Tool
      • KEGG Pathway Engine for use with CRISPR data, RNAi data, or gene expression data
      • Gene Query
      • Breast Cancer Cell Line Druggable Signature Tool
    • AU565 Breast Cancer Cell Line
    • The BT549 breast cancer cell line
    • The CAL51 Breast Cancer Cell Line
    • The CAMA1 Breast Cancer Cell Line
    • The EFM19 Breast Cancer Cell Line
    • The DU4475 Breast Cancer Cell Line
    • The BT20 Breast Cancer Cell Line
    • The CAL120 Breast Cancer Cell line
    • The HCC70 Breast Cancer Cell Line
    • The HCC202 Breast Cancer Cell Line
    • The HCC1143 Human Breast Cancer Cell Line
    • The HCC1187 Breast Cancer Cell Line
    • The HCC1395 Breast Cancer Cell Line
    • The HCC1419 Breast Cancer Cell Line
    • The HCC1428 Breast Cancer Cell Line
    • The HCC1500 Breast Cancer Cell Line
    • The HCC1569 Breast Cancer Cell Line
    • The HCC1806 Breast Cancer Cell Line
    • The HCC1937 Breast Cancer Cell Line
    • The HCC1954 Breast Cancer Cell Line
    • The HCC2218 Breast cancer cell line
    • The HMC18 breast cancer cell line
    • The Hs578T breast cancer cell line
    • The JIMT1 Human breast cancer cell line
    • The KPL1 Breast Cancer Cell Line
    • The MCF-7 Human Breast Cancer Cell Line
    • The MDA-MB-231 Breast Cancer Cell Line
    • The MDA-MB-468 breast cancer cell line
    • The MDA-MB-134VI breast cancer cell line
    • The MDA-MB-175VII breast cancer cell line
    • The MDA-MB-157 breast cancer cell line
    • The MDA-MB-361 Breast Cancer Cell Line
    • The MDA-MB-415 breast cancer cell line
    • The MDA-MB-436 breast cancer cell line
    • The MDA-MB-453 breast cancer cell line
    • The SKBR3 breast cancer cell line
    • The T47D breast cancer cell line
    • The UACC812 breast cancer cell line
    • The ZR7530 breast cancer cell line
    • The ZR751 breast cancer cell line
  • Data Mining Tools for all cancer cell lines
    • Gene Query, Oncogene Signature, and Genomic analysis app for all cancer cell lines
    • Expanded Cell Line Gene Query
    • Cancer Cell Line Oncogene Signature and Drug Sensitivity page
    • KEGG Pathway app for gene expression and gene essentiality data
  • The SLKBase BLOG!
  • Sextant Oncology LLC
Main Menu

KEGG canonical pathways enriched with data from the genome scale shRNA screen

Below is a sampling of key pathways showing how data from the shRNA screens map to each pathway.  For an analysis of any KEGG pathway using shRNA screen or gene expression data from SUM-149 cells, please go to the KEGG Pathway Engine page.

Cell Cycle

PI3’K/AKT signaling

mTOR signaling

ERBB signaling

MAPK signaling

WNT signaling

Apoptosis signaling

Back to SUM-149 Home

 

 

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