SUM-225 Oncogene Signatures

Candidate Oncogene Signature:  Genes genomically altered that are also OncoKB annotated

GeneSymbol DnaAmp LogFoldChange Mutation OccurencesInCOSMIC oncogene
ERBB2 5.1635 3.461473379 NULL 0 1
CDK6 2.0051 0.456753488 NULL 0 1
CYLD 1.5807 1.95338666 NULL 0 0
NUP93 1.5807 0.316660283 NULL 0 0
SPOP 1.5454 1.260326675 NULL 0 0
RECQL4 1.1621 -0.021761671 NULL 0 0
CTCF 1.1034 0.674085843 NULL 0 0
CDH1 1.1034 3.957255848 NULL 0 0
TP53 NULL 0.033311061 TP53p.L265P 15 0
Functional Oncogene Signature: Genes that are genomically altered and were hits in the RNAi screen
GeneSymbol DnaAmp LogFoldChange Mutation OccurencesInCOSMIC ScreenHit
ERBB2 5.1635 3.461473379 NULL 0 1
GRB7 5.1635 NULL NULL 0 1
ANKIB1 2.0051 1.826251001 NULL 0 1
CYP51A1 2.0051 NULL NULL 0 1
CNOT1 1.5807 1.197722129 NULL 0 1
MT1B 1.5807 1.056464975 NULL 0 1
POLR2C 1.5807 1.371796955 NULL 0 1
CAPNS2 1.5807 0.991520092 NULL 0 1
MT1M 1.5807 NULL NULL 0 1
CXCL3 1.4111 0.311927941 NULL 0 1
CDKL2 1.4111 0.733922814 NULL 0 1
ZNF707 1.1621 2.630070749 NULL 0 1
GPT 1.1621 -0.267366161 NULL 0 1
VPS28 1.1621 1.11920931 NULL 0 1
RPL8 1.1621 0.467632656 NULL 0 1
MAF1 1.1621 0.727440772 NULL 0 1
HSF1 1.1621 NULL NULL 0 1
PUF60 1.1621 NULL NULL 0 1
CYP11B1 1.1621 NULL NULL 0 1
BOP1 1.1621 NULL NULL 0 1
HNF4G 1.1365 -0.509918763 NULL 0 1
DNM1L 1.1123 0.343759796 NULL 0 1
CTRL 1.1034 0.258258804 NULL 0 1
ATP6V0D1 1.1034 0.865084207 NULL 0 1

Overall Oncogene Signature:  Genes that are amplified and overexpressed, or recurrently mutated, regardless of OncoKB or screen hit status

GeneSymbol DnaAmp LogFoldChange Mutation ScreenHit OccurencesInCOSMIC ExistingDrugs
C17ORF37 5.1635 2.977959645   0 0  
STARD3 5.1635 2.813234502   0 0  
ERBB2 5.1635 3.461473379   1 0 Lapatinib, CP724714, CUDC-101, Afatinib
PNMT 5.1635 2.196903351   0 0  
NEUROD2 5.1635 1.677343633   0 0  
ZBED4 2.6332 1.790417613   0 0  
TRABD 2.6332 1.778069325   0 0  
CRELD2 2.6332 2.449276978   0 0  
ALG12 2.6332 2.065810277   0 0  
PIM3 2.6332 2.487415916   0 0 PI-103, SL0101
MOV10L1 2.6332 1.383783333   0 0  
ERLIN2 2.2774 2.199825145   0 0  
PROSC 2.2774 2.273758916   0 0  
KRIT1 2.0051 1.558482859   0 0  
BET1 2.0051 2.210988718   0 0  
FZD1 2.0051 1.550523087   0 0  
MTERF 2.0051 1.786446725   0 0  
CASD1 2.0051 1.835646544   0 0  
GNGT1 2.0051 2.625363143   0 0  
GATAD1 2.0051 1.530019575   0 0  
ANKIB1 2.0051 1.826251001   1 0  
PEX1 2.0051 1.6207483   0 0  
PHKB 1.5807 1.726143438   0 0  
MT1X 1.5807 1.346507329   0 0  
POLR2C 1.5807 1.371796955   1 0  
MT1G 1.5807 1.09743437   0 0  
MT1B 1.5807 1.056464975   1 0  
HEATR3 1.5807 1.279707463   0 0  
OGFOD1 1.5807 1.365653406   0 0  
COQ9 1.5807 1.566618348   0 0  
ZNF319 1.5807 2.928215929   0 0  
C16ORF80 1.5807 1.144262683   0 0  
RBL2 1.5807 1.076277211   0 0  
CCL17 1.5807 1.32343476   0 0  
CCL22 1.5807 1.94027211   0 0  
CX3CL1 1.5807 2.085640027   0 0  
NOD2 1.5807 4.341506327   0 0  
AKTIP 1.5807 2.533514734   0 0  
AMFR 1.5807 1.96087106   0 0  
NDRG4 1.5807 1.321438   0 0  
SLC6A2 1.5807 1.764637859   0 0  
HERPUD1 1.5807 2.848758877   0 0  
CNOT1 1.5807 1.197722129   1 0  
GPR56 1.5807 2.7040897   0 0  
IRX3 1.5807 2.068849256   0 0  
CES7 1.5807 1.59727593   0 0  
SETD6 1.5807 1.68853022   0 0  
CHD9 1.5807 1.350782968   0 0  
CYLD 1.5807 1.95338666   0 0  
ITFG1 1.5807 1.393862805   0 0  
NETO2 1.5807 2.003886496   0 0  
CSNK2A2 1.5807 1.107058733   0 0  
IRX5 1.5807 3.118550536   0 0  
DNAJA2 1.5807 1.86817313   0 0  
SPOP 1.5454 1.260326675   0 0  
ZNF652 1.5454 1.113553857   0 0  
SLC35B1 1.5454 1.197148113   0 0  
TP53   0.033311061 TP53p.L265P 0 15